Built in 1630 by Baldassare Longhena to ward off a plague epidemic, this immense church crowned with a domed and standing almost exactly at the mouth of the Grand Canal, is one of the best-known sites of Venice. If the interior can seem quite cold within its majestic solemnity, it does contain some priceless works of art: The Wedding of Cana by Tintoretto, and works by Titian whose topic is sacrifice (ceiling of the Sacristy) and altarpieces by Luca Giordano.