A masterpiece of Isabeline Gothic both for the unity of style as well as the richness of its ornamentation, which is by Enrique Egas. Inside, don't miss the spectacular grill of Bartholomew of Jaén which closes in the transept and in which is the mausoleum of the Catholic Monarchs and that of their daughter Juana the Mad and of her husband. The museum has valuable historical objects and an extraordinary collection of works by Spanish, Flemish and Italian masters.