Long a mainstay on this bustling stretch of Polk Street, Pesce is an easygoing seafood bar where the locals get along swimmingly. Serving Italian small plates known as cicchetti, the restaurant is particularly beloved among neighborhood types who like to catch up over a quick glass of wine and a snack-think plump grilled sardines with pickled root vegetables-at the long zinc bar. For those who've come to stay a while, simple wood furniture, penny tile floors, and that ever-friendly service make for a comfortable vibe in the narrow ambient space. Look for popular dishes like grilled Monterey calamari with caramelized fennel and spicy pomodoro sauce; Dungeness crab with cucumber and avocado; squid ink risotto; and fresh oyster shots spiked with horseradish.